Publications

Cahlíková, L., Kawano, I., Řezáčová, M., Blunden G, Hulcová D, Havelek R:  TheAmaryllidaceaealkaloidshaemanthamine, haemanthidine and theirsemisyntheticderivatives as potentialdrugs. PhytochemRev. 2021; 20: 303–323. https://doi.org/10.1007/s11101-020-09675-8 IF 7,7 

Koutova D, Maafi N, Muthna D, Kralovec K, Kroustkova J, Pidany F, Timbilla AA, Cermakova E, Cahlikova L, Rezacova M, Havelek R. Antiproliferativeactivity and apoptosis-inducingmechanismofAmaryllidaceae alkaloid montanine on A549 and MOLT-4 humancancercells. BiomedPharmacother. 2023;166:115295. doi: 10.1016/j.biopha.2023.115295. IF 7,5 

Gorecki L, Muthna D, Merdita S, Andrs M, Kucera T, Havelek R, Muckova L, Kobrlova T, Soukup J, Krupa P, Prchal L, Soukup O, Roh J, Rezacova M, Korabecny J: 7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as corestructuresfor novel anticanceragentswithpotentialchemosensitizingproperties. Eur J Med Chem. 2022;240:114580. doi: 10.1016/j.ejmech.2022.114580 IF 6,7 

An alternativeapproach to validationofliquidchromatography-massspectrometrymethodsforthequantificationofendogenouscompounds. Uher M., Mičuda S., Kacerovský M., Hroch M. J. Chromatogr. A, 2023, 30:1705:464173. IF = 4.6 

Mrkvicová A, Peterová E, Nemec I, Křikavová R, Muthná D, Havelek R, Kazimírová P, Řezáčová M, Štarha P: Rh(III) and Ru(II) complexeswithphosphanyl-alkylamines: inhibitionof DNA synthesisinduced by anticancerRhcomplex. Future Med Chem. 2023. doi: 10.4155/fmc-2023-0170 IF 4,2 

Masaryk L, Muthná D, Halaš P, Zoufalý P, Peterová E, Havelek R, Drahoš B, Milde D, Mrkvicová A, Štarha P.: Stability of a half-sandwichOs(II) complexwithindomethacin-functionalized ligand in the presence ofcarboxypeptidase A.  Dalton Trans. 2022;51(24):9213-9217. doi: 10.1039/d2dt01085b IF 4,0 

High-throughputsalting-out assistedliquid-liquidextractionusing a 3Dprinteddevice and itsapplication in thequantificationofibrutinib and its metabolite PCI-45227 in humanserum. 

Écsiová D, Šimkovič M, Uher M, Hroch M. J Pharm BiomedAnal. 2022; 219:114923. IF = 3.6 

Patents

Anticancer compounds based on nitrogen heterocycles, their use as drugs and pharmaceutical preparations containing them. Czech patent deed (patent file), patent number 309579. Issued on 15.3.2023.

1-aryloxy-3-(4-(2-hydroxyethyl)piperazin-1-yl)propan-2-ols, method of their preparation and their use. Czech patent deed (patent file), patent number 309081. Issued on 14.1.2022.

Others

DSP Medical Chemistry and Biochemistry student Mgr. Darja Koutová, Ph.D. (supervisor doc. Havelek) won the Mayor of Hradec Králové Award for student creative work in 2020.

DSP Medical Chemistry and Biochemistry student Mgr. Darja Koutová, Ph.D. (supervisor doc. Havelek) also won the 1st prize at the DSP LF UK HK student conference in 2021.